E ISSN 2791-7851
Volume : 3 Issue : 2 Year : 2023
Journal of Multiple Sclerosis Research
Determination of <i>SIRT7, SEMA3A, SEMA3F</i> Gene Expressions in Patients with Multiple Sclerosis [J Mult Scler Res]
J Mult Scler Res. 2023; 3(2): 24-29 | DOI: 10.4274/jmsr.galenos.2023.2023-9-1

Determination of SIRT7, SEMA3A, SEMA3F Gene Expressions in Patients with Multiple Sclerosis

Feti Cetin1, Yigit Can Güldiken2, Kursat Kargun3, Caner Feyzi Demir4
1Tunceli State Hospital, Clinic of Neurology, Tunceli, Turkey
2Bahcesehir University, Goztepe Medical Park Hospital, Clinic of Neurology, Istanbul, Turkey
3Firat University, Vocational School of Health Services, Department of Medical Laboratory, Elazig, Turkey
4Firat University Faculty of Medicine, Department of Neurology, Elazig, Turkey

INTRODUCTION: In this study, we aimed to analyze the expression levels of specific genes that may contribute to the pathogenesis of multiple sclerosis (MS) in patients and explore the applicability of biomarkers. These biomarkers could serve as valuable diagnostic and prognostic tools, contributing to a better understanding of disease etiology, facilitating disease monitoring, and evaluating treatment efficacy.
METHODS: We analyzed the expression levels of SIRT7, SEMA3A, and SEMA3F genes using samples obtained from both MS patients and healthy controls.
RESULTS: Our research findings suggest that these genes have increased expression in the specific tissues of patients with MS, with blood samples showing the most pronounced increase in their expression levels.
DISCUSSION AND CONCLUSION: Although these increases were not statistically significant, our study provides valuable insights for further research on gene expression in MS patients. This study demonstrates that potential biomarkers are essential in comprehending the molecular basis of MS. Additional research is needed to substantiate the findings presented in our study and enhance our understanding of the role of genes in the pathogenesis of MS.

Keywords: Multiple sclerosis, SIRT7, SEMA3A, SEMA3F

Feti Cetin, Yigit Can Güldiken, Kursat Kargun, Caner Feyzi Demir. Determination of SIRT7, SEMA3A, SEMA3F Gene Expressions in Patients with Multiple Sclerosis. J Mult Scler Res. 2023; 3(2): 24-29

Corresponding Author: Feti Cetin, Türkiye
Manuscript Language: English
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