E ISSN 2791-7851
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Volume: 2 Issue: 2 Year: 2022
HPV-associated Anal and Genital Intraepithelial Neoplasia After Using Fingolimod in the Treatment of Relapsing-remitting Multiple Sclerosis: A Case Report [J Mult Scler Res]
J Mult Scler Res. 2022; 2(1): 28-30 | DOI: 10.4274/jmsr.galenos.2022.2022-3-2

HPV-associated Anal and Genital Intraepithelial Neoplasia After Using Fingolimod in the Treatment of Relapsing-remitting Multiple Sclerosis: A Case Report

Melis Doganay Ocalan1, Gulin Morkavuk1, Asli Yarci Gursoy2, Suleyman Ozdemir3, Alev Leventoglu1
1Ufuk University Faculty of Medicine, Department of Neurology, Ankara, Turkey
2Ufuk University Faculty of Medicine, Department of Gynecology and Obstetrics, Ankara, Turkey
3Ufuk University, Faculty of Medicine, Department of General Surgery, Ankara, Turkey

Multiple sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease of the central nervous system, with inflammation and loss of myelin in axons. Fingolimod is the first oral disease-modifying agent approved for the treatment of relapsing-remitting MS. Here we aimed to present a patient with MS who developed human papillomavirus (HPV)-associated anal and genital intraepithelial neoplasia while on fingolimod treatment. A 19-year-old female patient presented with the complaint of diplopia. The diagnosis of MS was made based on imaging and cerebrospinal fluid results. She was treated first with beta-interferon 1a, then methotrexate, and finally fingolimod. While the patient was being followed without attack under fingolimod treatment, HPV-associated genital, and further, anal warts developed. This is a rare case that developed both cervical dysplasia and anal Condyloma acuminatum due to the HPV that developed after fingolimod treatment in a patient with MS. In conclusion, fingolimod treatment increases the risk of cervical HPV infection and related cancer in patients with MS.

Keywords: Multiple sclerosis, relapsing-remitting, fingolimod, HPV, cervical dysplasia

Melis Doganay Ocalan, Gulin Morkavuk, Asli Yarci Gursoy, Suleyman Ozdemir, Alev Leventoglu. HPV-associated Anal and Genital Intraepithelial Neoplasia After Using Fingolimod in the Treatment of Relapsing-remitting Multiple Sclerosis: A Case Report. J Mult Scler Res. 2022; 2(1): 28-30

Corresponding Author: Gulin Morkavuk, Türkiye
Manuscript Language: English
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